Abstract | INTRODUCTION: METHODS: RESULTS: The results showed that all of the drugs were characterized by dose-dependent toxicity, which was greatest in the case of chlorpromazine (IC90 = 10.02 +/- 0.69 microg/mL), followed by olanzapine (IC90 = 13.43 +/- 1.23 microg/mL), clozapine (IC90 = 44.71 +/- 4.42 microg/mL), and quetiapine (IC90 = 137.24 +/- 15.36 microg/mL). DISCUSSION: These data agree with recent clinical reports concerning the direct or mediated toxic effects of olanzapine on progenitor and committed cells (GM-CFU) and suggest that the correlation between its plasma levels and clinical effects warrants further investigation. There are no published data concerning the bone marrow pharmacokinetics of atypical antipsychotics or their possible bioactivation by the bone marrow cell compartment, but our findings suggest that they may affect hematopoiesis in different ways, such as the direct action of them or their metabolites due to bioactivation by hematopoietic cells themselves.
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Authors | A Pessina, E Turlizzi, A Bonomi, F Guizzardi, L Cavicchini, C Croera, S Bareggi |
Journal | Pharmacopsychiatry
(Pharmacopsychiatry)
Vol. 39
Issue 1
Pg. 20-2
(Jan 2006)
ISSN: 0176-3679 [Print] Germany |
PMID | 16453250
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antipsychotic Agents
- Dibenzothiazepines
- Benzodiazepines
- Quetiapine Fumarate
- Clozapine
- Olanzapine
- Chlorpromazine
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Topics |
- Antipsychotic Agents
(pharmacology)
- Benzodiazepines
(pharmacology)
- Chlorpromazine
(pharmacology)
- Clozapine
(pharmacology)
- Colony-Forming Units Assay
- Dibenzothiazepines
(pharmacology)
- Dose-Response Relationship, Drug
- Granulocytes
(drug effects)
- Hematopoietic Stem Cells
(drug effects)
- Humans
- Macrophages
(drug effects)
- Olanzapine
- Quetiapine Fumarate
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