Angioedema from angiotensin-converting enzyme (ACE) inhibitor treated with complement 1 (C1) inhibitor concentrate.

Abstract

BACKGROUND:

Up to seven in every 1000 patients experience angioedema from angiotensin-converting enzyme (ACE) inhibitors, even after many years of use. In 2003, every 20th Norwegian used an ACE inhibitor.

CASE REPORT:

A 61-year-old woman with chronic obstructive pulmonary disease and a past acute myocardial infarction had used 7.5 mg of ramipril daily for the past 7 years. She also used acetylsalicylic acid, simvastatin, theophylline and salmeterol. One night she woke up with edema of the tongue. On hospital arrival, 250 mg of hydrocortisone and 5 mg of dexchlorpheniramine were given intravenously (i.v.) and 0.3 mg of epinephrine was given subcutaneously (s.c.). The edema of the tongue progressed over the next 8 h and made the tongue protrude. Fiberscopy revealed glassy edema of the arytenoids. Inspiratory stridor was heard and the patient could not speak. She became increasingly uneasy and restless. Berinert complement 1 (C1) inhibitor concentrate (1500 units) was administered i.v. Over the following 20 min, stridor gradually subsided, the patient calmed and she was able to talk.

DISCUSSION:

ACE inhibitor-provoked angioedema shares many clinical features with hereditary angioedema (HAE), including a limited effect of steroids, antihistamines and epinephrine. HAE, caused by excess bradykinin formation as a result of C1 inhibitor deficiency, usually has its laryngeal edema effectively reversed by C1 inhibitor in less than 0.5 h. Although patients experiencing ACE inhibitor-provoked angioedema have normal C1 inhibitor values, as in our patient, excess bradykinin is probably important as ACE breaks down bradykinin. It is unknown why ACE inhibitor-provoked angioedema appears in some and sometimes after many years of use.

CONCLUSION:

We believe that C1 inhibitor was effective in reversing the ACE inhibitor-induced angioedema in our patient.

• Authors: E W Nielsen, S Gramstad
• Journal: Acta anaesthesiologica Scandinavica (Acta Anaesthesiol Scand) Vol. 50 Issue 1 Pg. 120-2 (Jan 2006) ISSN: 0001-5172 [Print] England
• PMID: 16451161 (Publication Type: Case Reports, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Complement C1 Inactivator Proteins

Topics

• Airway Obstruction (etiology)
• Angioedema (chemically induced, drug therapy)
• Angiotensin-Converting Enzyme Inhibitors (adverse effects)
• Complement C1 Inactivator Proteins (therapeutic use)
• Female
• Humans
• Middle Aged
• Tongue Diseases (chemically induced, diagnosis)