Abstract | OBJECTIVE: DATA SOURCES: Information was selected from PubMed (1965-October 2005). All studies presented as scientific posters and abstracts from nephrology meetings from 1999 to 2005 were also included. STUDY SELECTION AND DATA EXTRACTION: All published articles regarding lanthanum carbonate were included. In addition, abstracts and presentations from scientific meeting symposia were also considered for inclusion. DATA SYNTHESIS:
Lanthanum carbonate has been recently approved as non- calcium-based therapy for phosphate reduction in patients with stage 5 CKD requiring dialysis. The recommended dose is 250-500 mg with meals, for a maximum of 1500 mg daily. Clinical studies have shown short- and long-term safety with lanthanum carbonate administration. Adverse effects were primarily gastrointestinal in nature. Clinical trials have also shown reductions in serum phosphorus to target concentrations, reductions in associated calcium- phosphorus product, and minimal effects on serum calcium and parathyroid hormone concentrations. CONCLUSIONS:
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Authors | Melanie S Joy, Abhijit Kshirsagar, Corina Candiani, Tyson Brooks, Joanna Q Hudson |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 40
Issue 2
Pg. 234-40
(Feb 2006)
ISSN: 1060-0280 [Print] United States |
PMID | 16449551
(Publication Type: Journal Article, Review)
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Chemical References |
- Phosphorus
- lanthanum carbonate
- Lanthanum
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Topics |
- Animals
- Chronic Disease
- Clinical Trials as Topic
- Humans
- Kidney Diseases
(blood, drug therapy)
- Lanthanum
(adverse effects, pharmacokinetics, pharmacology, therapeutic use)
- Phosphorus
(blood)
- Treatment Outcome
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