Abstract | BACKGROUND/AIMS: PATIENTS AND METHODS: RESULTS: Unlike coagulation factors II, V or VII, factor XIII activity was maintained in the majority of patients with liver cirrhosis. However, although rarely, factor XIII deficiencies (<50%) occurred, especially in Child C cirrhosis. Factor XIII levels correlated with liver's biosynthetic capacity ( cholinesterase activity, albumin, total protein) as well as with platelet count, global coagulation tests and other single coagulation factors. Patients reporting a current systemic bleeding tendency at study entry had significantly reduced factor XIII. In a 6-year follow-up, patients with factor XIII<50% had a significantly increased risk of severe upper gastrointestinal bleed, and reduced factor XIII (<50%, 50-75% vs. normal) was associated with increased mortality. CONCLUSIONS:
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Authors | Frank Tacke, Kai Fiedler, Mario von Depka, Tom Luedde, Hartmut Hecker, Michael P Manns, Arnold Ganser, Christian Trautwein |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 26
Issue 2
Pg. 173-81
(Mar 2006)
ISSN: 1478-3223 [Print] United States |
PMID | 16448455
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Blood Coagulation Disorders
(blood, diagnosis, etiology, mortality)
- Chronic Disease
- Factor XIII
(metabolism)
- Female
- Humans
- Liver Cirrhosis
(blood, complications, diagnosis, mortality)
- Male
- Middle Aged
- Prognosis
- Proportional Hazards Models
- Prospective Studies
- Prothrombin Time
(classification)
- Survival Rate
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