Abstract |
Feitai, a Chinese medicine formulation, has been shown to protect against lung fibrosis induced by bleomycin (BLM). In the present study, we investigated the effect of Feitai on transforming growth factor (TGF)-beta1 and monocyte chemoattractant protein-1 (MCP-1), which play important roles in the pathogenesis of BLM-induced lung fibrosis. The results demonstrated that Feitai could significantly attenuate BLM-induced acute lung inflammation and subsequent lung fibrosis. Meanwhile, the expression of MCP-1 and TGF-beta1 mRNA in the lungs increased in the BLM-treated group compared with the saline-instilled control group and Feitai treatment significantly decreased cytokine expression in BLM-treated mice. In addition, Feitai diminished the accumulation of MCP-1- and TGF-beta1-positive cells in lung tissues at the time of peak mRNA levels. In summary, the results of the present study indicate that treatment with Feitai ameliorates BLM-induced lung fibrosis, at least in part via the inhibition of MCP-1 and TGF-beta1 expression.
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Authors | Yun Shen, Hao-Long Zhao, Juan Du, Yu-Ting Li, Fang Tan, Cheng-Gang Huang, Gang Pei |
Journal | Clinical and experimental pharmacology & physiology
(Clin Exp Pharmacol Physiol)
Vol. 32
Issue 12
Pg. 1071-7
(Dec 2005)
ISSN: 0305-1870 [Print] Australia |
PMID | 16445573
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Ccl2 protein, mouse
- Chemokine CCL2
- Drugs, Chinese Herbal
- Feitai
- Tgfb1 protein, mouse
- Transforming Growth Factor beta
- Transforming Growth Factor beta1
- Bleomycin
- Peroxidase
- Hydroxyproline
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Topics |
- Animals
- Anti-Bacterial Agents
- Bleomycin
- Cell Differentiation
(drug effects)
- Chemokine CCL2
(biosynthesis)
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Female
- Fibroblasts
(drug effects)
- Hydroxyproline
(metabolism)
- Immunohistochemistry
- Lung
(pathology)
- Mice
- Mice, Inbred C57BL
- Peroxidase
(metabolism)
- Pulmonary Fibrosis
(chemically induced, metabolism, prevention & control)
- Reverse Transcriptase Polymerase Chain Reaction
- Transforming Growth Factor beta
(biosynthesis)
- Transforming Growth Factor beta1
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