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Feitai, a Chinese herbal medicine, reduces transforming growth factor-beta1 and monocyte chemoattractant protein-1 expression in bleomycin-induced lung fibrosis in mice.

Abstract
Feitai, a Chinese medicine formulation, has been shown to protect against lung fibrosis induced by bleomycin (BLM). In the present study, we investigated the effect of Feitai on transforming growth factor (TGF)-beta1 and monocyte chemoattractant protein-1 (MCP-1), which play important roles in the pathogenesis of BLM-induced lung fibrosis. The results demonstrated that Feitai could significantly attenuate BLM-induced acute lung inflammation and subsequent lung fibrosis. Meanwhile, the expression of MCP-1 and TGF-beta1 mRNA in the lungs increased in the BLM-treated group compared with the saline-instilled control group and Feitai treatment significantly decreased cytokine expression in BLM-treated mice. In addition, Feitai diminished the accumulation of MCP-1- and TGF-beta1-positive cells in lung tissues at the time of peak mRNA levels. In summary, the results of the present study indicate that treatment with Feitai ameliorates BLM-induced lung fibrosis, at least in part via the inhibition of MCP-1 and TGF-beta1 expression.
AuthorsYun Shen, Hao-Long Zhao, Juan Du, Yu-Ting Li, Fang Tan, Cheng-Gang Huang, Gang Pei
JournalClinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) Vol. 32 Issue 12 Pg. 1071-7 (Dec 2005) ISSN: 0305-1870 [Print] Australia
PMID16445573 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Ccl2 protein, mouse
  • Chemokine CCL2
  • Drugs, Chinese Herbal
  • Feitai
  • Tgfb1 protein, mouse
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1
  • Bleomycin
  • Peroxidase
  • Hydroxyproline
Topics
  • Animals
  • Anti-Bacterial Agents
  • Bleomycin
  • Cell Differentiation (drug effects)
  • Chemokine CCL2 (biosynthesis)
  • Drugs, Chinese Herbal (pharmacology, therapeutic use)
  • Female
  • Fibroblasts (drug effects)
  • Hydroxyproline (metabolism)
  • Immunohistochemistry
  • Lung (pathology)
  • Mice
  • Mice, Inbred C57BL
  • Peroxidase (metabolism)
  • Pulmonary Fibrosis (chemically induced, metabolism, prevention & control)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transforming Growth Factor beta (biosynthesis)
  • Transforming Growth Factor beta1

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