| Abstract | We enrolled 11 patients with refractory graft-versus-host disease (GVHD) in a prospective trial evaluating the efficacy of mycophenolate mofetil (MMF). Four (67%) of the 6 patients with acute GVHD and all 5 patients with chronic GVHD responded to MMF.Ten (91%) of the 11 patients were able to decrease steroid use (median decrease, 86%; range, 25%-100%). After a median follow-up of 18 months (range, 1-65 months), 7 patients (64%) remained alive. The adverse events were infectious complications (36%), diarrhea (27%), and neutropenia (18%); the only patient discontinuing MMF did so because of grade 4 neutropenia.This preliminary study suggests that MMF is a well-tolerated agent and has a beneficial effect in the treatment of refractory acute and chronic GVHD. |
| Authors | Akiyoshi Takami, Kanako Mochizuki, Hirokazu Okumura, Satsuki Ito, Yukio Suga, Hirohito Yamazaki, Masahide Yamazaki, Yukio Kondo, Hidesaku Asakura, Shinji Nakao
(Affiliation: Department of Cellular Transplantation Biology, University Graduate School of Medicine, Kanazawa, Japan. takami at med3.m.kanazawa-u.ac.jp)
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| Journal | International journal of hematology
(Int J Hematol)
Vol. 83
Issue 1
Pg. 80-5
(Jan 2006)
ISSN: 0925-5710 United States |
| PMID | 16443558
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
- Immunosuppressive Agents
- mycophenolate mofetil
- Mycophenolic Acid
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| Topics |
- Acute Disease
- Adult
- Aged
- Chronic Disease
- Female
- Follow-Up Studies
- Graft vs Host Disease
(drug therapy, etiology)
- Humans
- Immunosuppressive Agents
(administration & dosage, adverse effects)
- Lymphoproliferative Disorders
(complications, therapy)
- Male
- Middle Aged
- Mycophenolic Acid
(administration & dosage, adverse effects, analogs & derivatives)
- Prospective Studies
- Stem Cell Transplantation
(adverse effects, methods)
- Transplantation, Homologous
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