Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature.

Abstract

BACKGROUND:

Malignant acanthosis nigricans is a mucocutaneous eruption associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. The sign of Leser-Tre'lat is the presence of multiple seborrheic keratoses and scattered skin tags caused by a malignancy. We are reporting the first case of ovarian cancer in association with three coexisting cutaneous paraneoplastic dermatosis.

CASE:

A 52-year-old female presented with skin manifestation consistent with MAN, TP and the sign of Leser-Tre'lat. Patient underwent extensive work up and was discovered to have stage I, high grade adenocarcinoma of the ovary. Skin manifestations gradually recovered after initiation of chemotherapy.

CONCLUSION:

The presence of acanthosis nigricans in conjunction with tripe palms and the sign of Leser-Tre'lat are highly suggestive of an internal malignancy and necessitate an extensive investigation in order to discover the underlying malignancy.

• Authors: Mehdi M Kebria, Jerome Belinson, Robert Kim, Tarek M Mekhail
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 101 Issue 2 Pg. 353-5 (May 2006) ISSN: 0090-8258 [Print] United States
• PMID: 16443260 (Publication Type: Case Reports, Journal Article)

Topics

• Acanthosis Nigricans (complications)
• Female
• Hand Dermatoses (complications)
• Humans
• Keratoderma, Palmoplantar (complications)
• Keratosis, Seborrheic (complications)
• Middle Aged
• Ovarian Neoplasms (complications, diagnosis)
• Paraneoplastic Syndromes (complications)
• Skin Diseases (complications)