Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein.

Abstract

Human T-cell leukemia virus type 1 is an oncogenic retrovirus etiologically causal of adult T-cell leukemia. The virus encodes a Tax oncoprotein, which functions in transcriptional regulation, cell cycle control, and transformation. Because adult T-cell leukemia is a highly virulent cancer that is resistant to numerous chemotherapeutic treatments, to understand better this disease it is important to comprehend how human T-cell leukemia virus type 1 promotes cellular growth and survival. Most of the existing data point to Tax activation of NF-kappaB as important for cellular proliferation and transformation. We show here that Tax, in the absence of NF-kappaB signaling, can activate activator protein-1 to promote cellular proliferation and survival. Tax is shown to activate activator protein-1 through the phosphatidylinositol 3-kinase/Akt pathway.

• Authors: Jean-Marie Peloponese Jr, Kuan-Teh Jeang
• Journal: The Journal of biological chemistry (J Biol Chem) Vol. 281 Issue 13 Pg. 8927-38 (Mar 31 2006) ISSN: 0021-9258 [Print] United States
• PMID: 16436385 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• Gene Products, tax
• Transcription Factor AP-1
• Luciferases
• Proto-Oncogene Proteins c-akt
• beta-Galactosidase

Topics

• Animals
• Cell Line, Transformed
• Cell Proliferation
• Cell Transformation, Viral
• Cells, Cultured
• Chlorocebus aethiops
• Fibroblasts (metabolism, virology)
• Gene Expression Regulation, Viral
• Gene Products, tax (genetics, metabolism, physiology)
• Genes, Reporter
• Human T-lymphotropic virus 1 (physiology)
• Humans
• Jurkat Cells
• Luciferases (metabolism)
• Mice
• Phosphatidylinositol 3-Kinases (metabolism)
• Proto-Oncogene Proteins c-akt (analysis, metabolism, physiology)
• T-Lymphocytes (metabolism, virology)
• Transcription Factor AP-1 (metabolism, physiology)
• Vero Cells
• beta-Galactosidase (analysis, metabolism)