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Known and new delta globin gene mutations and their diagnostic significance.

Abstract
Mutations in the delta-globin gene (HBD, MIM# 142000) are not pathologically relevant. However, since high HbA2 levels are diagnostic for beta-thalassemia trait and a lowered level for an alpha- or delta-mutation, co-inheritance of delta- and beta-gene defects may lead to misinterpretation of diagnostic results. We examined 29 cases with low HbA2 level diagnosed in our laboratory, in the presence or absence of a second HbA2 fraction. We found a delta globin gene mutation in 20 cases. In total four different known mutations were found, three structural and one expressional. Moreover, two new defects were observed, one causing a structural abnormality and one a beta-thalassemia. The structural abnormality HBD c.431A->G (p.His144Arg)(dcd 143 CAC->CGC) was homologous to the beta-globin gene variant called Hb-Abruzzo and we have named this mutation HbA2 -Abruzzo. The new delta-thalassemia defect HBD c.-118C->T (d -68 C->T) has no homology on the beta-globin gene (HBB, MIM# 141900). All mutations caused a low HbA2 level and through this could lead to misdiagnosis when inherited together with a beta-thalassemia.
AuthorsMarelle J Bouva, Cornelis L Harteveld, Peter van Delft, Piero C Giordano
JournalHaematologica (Haematologica) Vol. 91 Issue 1 Pg. 129-32 (Jan 2006) ISSN: 1592-8721 [Electronic] Italy
PMID16434382 (Publication Type: Journal Article)
Chemical References
  • Hemoglobins, Abnormal
  • hemoglobin Abruzzo
  • Globins
  • Hemoglobin A2
Topics
  • Globins (genetics)
  • Hemoglobin A2 (analysis)
  • Hemoglobins, Abnormal (genetics)
  • Humans
  • Point Mutation
  • beta-Thalassemia (diagnosis)

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