Abstract | PROBLEM: METHODS OF STUDY: Twenty-seven threatened aborters were treated for 10 days with dydrogesterone (30-40 mg/day). Sixteen healthy pregnant controls received no treatment. Serum cytokine concentrations were measured twice in both groups by enzyme-linked immunosorbent assay. RESULTS: Mean serum concentrations of Th1- and Th2-type cytokines in women with TA did not differ from those in women with normal pregnancy at first and second sampling. After dydrogesterone supplementation, mean TNF-alpha/IL-10 ratio changed from 1.08 to 1.75 while IL-12/IL-10 ratio remained almost the same (0.56-0.61) in the threatened aborters group and did not differ from those in healthy women. CONCLUSIONS: The results of this study indicate that peripheral cytokine production in threatened aborters does not differ from that observed among healthy pregnant women. The protective effect of dydrogesterone supplementation in threatened aborters is manifested via restoring progesterone-induced blocking factor concentration rather than controlling cytokine production.
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Authors | Jarosław Kalinka, Michał Radwan |
Journal | American journal of reproductive immunology (New York, N.Y. : 1989)
(Am J Reprod Immunol)
Vol. 55
Issue 2
Pg. 115-21
(Feb 2006)
ISSN: 1046-7408 [Print] Denmark |
PMID | 16433830
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Abortion, Threatened
(prevention & control)
- Case-Control Studies
- Cytokines
(blood)
- Dydrogesterone
(pharmacology)
- Female
- Humans
- Pregnancy
- Pregnancy Complications
- Pregnancy Outcome
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