Abstract |
A concise approach to the laboratory synthesis of garsubellin A is described. Garsubellin A, an effective inducer of choline acetyltransferase (ChAT), has been shown to have potential as a therapeutic agent for the treatment of Alzheimer's disease. Starting from 3,5-dimethoxyphenol, the synthesis has provided garsubellin A in an 18-step sequence. Notable transformations include dearomative allylation, diastereoselective vinylogous lactonization, iodocarbocyclization, transannular Wurtz, and bridgehead functionalization reactions.
|
Authors | Dionicio R Siegel, Samuel J Danishefsky |
Journal | Journal of the American Chemical Society
(J Am Chem Soc)
Vol. 128
Issue 4
Pg. 1048-9
(Feb 01 2006)
ISSN: 0002-7863 [Print] United States |
PMID | 16433500
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
|
Topics |
- Garcinia
(chemistry)
- Terpenes
(chemical synthesis)
|