Abstract | INTRODUCTION: METHODS: Preliminary data from a number of studies have been reviewed. RESULTS: There are emerging evidence-based benefits to using the combination of testoterone and PDE5 inhibitors. A recently published multicenter, randomized, placebo-controlled study evaluated the safety and efficacy of testosterone gel 1% plus sildenafil vs. placebo gel plus sildenafil, in producing an erectile response in hypogonadal men who had failed prior sildenafil alone for ED. Screening yielded a prevalence of hypogonadism in ED patients who failed prior sildenafil. Following randomization, the double-blinded treatment phase was 12 weeks. Testosterone therapy with testosterone gel significantly improved erectile function in response to sildenafil. In addition, it significantly improved orgasmic function and patient satisfaction. CONCLUSION:
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Authors | Ridwan Shabsigh |
Journal | The journal of sexual medicine
(J Sex Med)
Vol. 2
Issue 6
Pg. 785-92
(Nov 2005)
ISSN: 1743-6095 [Print] Netherlands |
PMID | 16422803
(Publication Type: Journal Article, Review)
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Chemical References |
- Androgens
- Gels
- Phosphodiesterase Inhibitors
- Piperazines
- Purines
- Sulfones
- Testosterone
- Sildenafil Citrate
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Topics |
- Androgens
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Erectile Dysfunction
(drug therapy)
- Gels
- Humans
- Hypogonadism
(drug therapy)
- Male
- Models, Animal
- Phosphodiesterase Inhibitors
(administration & dosage, therapeutic use)
- Piperazines
(administration & dosage, therapeutic use)
- Purines
- Sildenafil Citrate
- Sulfones
- Testosterone
(administration & dosage, therapeutic use)
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