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Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion.

Abstract
The effect of melatonin, a chronobiotic drug, was explored in 29 patients with chronic fatigue syndrome (CFS) and Dim Light Melatonin onset (DLMO) later than 21.30 hours, reflective of delayed circadian rhythmicity. The patients took 5 mg of melatonin orally, 5 h before DLMO during 3 months. Their responses to the checklist individual strength (CIS), a reliable questionnaire measuring the severity of personally experienced fatigue, were assessed twice with a 6-week interval immediately before the treatment and once after 3 months treatment. In the pre-treatment period the fatigue sub-score improved significantly. After treatment, the total CIS score and the sub-scores for fatigue, concentration, motivation and activity improved significantly. The sub-score fatigue normalized in two of the 29 patients in the pre-treatment period and in eight of 27 patients during treatment. This change was significant. In the patients with DLMO later than 22.00 hours (n=21) the total CIS score and the sub-scores for fatigue, concentration and activity improved significantly more than in the patients (n=8) with DLMO earlier than 22.00 hours. Melatonin may be an effective treatment for patients with CFS and late DLMO, especially in those with DLMO later than 22.00 hours.
AuthorsR O van Heukelom, J B Prins, M G Smits, G Bleijenberg
JournalEuropean journal of neurology (Eur J Neurol) Vol. 13 Issue 1 Pg. 55-60 (Jan 2006) ISSN: 1351-5101 [Print] England
PMID16420393 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Melatonin
Topics
  • Circadian Rhythm (drug effects)
  • Drug Administration Schedule
  • Fatigue Syndrome, Chronic (drug therapy)
  • Humans
  • Melatonin (administration & dosage, metabolism)
  • Sleep Initiation and Maintenance Disorders (drug therapy)
  • Time Factors
  • Treatment Outcome

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