Abstract | BACKGROUND: METHODS: We studied 10 junctional, 10 compound, and 10 intradermal nevi diagnosed by clinical and histological studies and by performing immunohistochemical study to assess MT1-MMP activity. RESULTS: We found evidence of MT1-MMP expression in melanocytic nevus cells, particularly around the entire border of cell nests. Expression was more intense in junctional nevi and gradually decreased with acquisition of intradermal component and became nonexistent in nevi in the deep dermis. CONCLUSIONS:
MT1-MMP is expressed in the membrane of nevus cells, with expression greater in nest cells in contact with the extracellular matrix. The intensity of expression correlated inversely with the maturation phase of the nevus, being very high in junctional nevi and low in intradermal nevi.
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Authors | L J Pérez, P F Peñas, M Atienzar, A García-Díez |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 33
Issue 2
Pg. 139-44
(Feb 2006)
ISSN: 0303-6987 [Print] United States |
PMID | 16420309
(Publication Type: Journal Article)
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Chemical References |
- Matrix Metalloproteinases
- Matrix Metalloproteinases, Membrane-Associated
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Topics |
- Adolescent
- Adult
- Aged
- Female
- Humans
- Immunohistochemistry
- Male
- Matrix Metalloproteinases
(biosynthesis)
- Matrix Metalloproteinases, Membrane-Associated
- Middle Aged
- Nevus, Pigmented
(metabolism, pathology)
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