Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like).

Abstract

PURPOSE:

To evaluate the safety and efficacy of photodynamic therapy with verteporfin (PDT) for subfoveal classic choroidal neovascularization (CNV) related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like).

METHODS:

Retrospective review of 16 eyes from 14 patients with subfoveal classic CNV associated with PIC or POHS-like and treated with PDT.

RESULTS:

The mean visual acuity increased from 4.5/10 (range: 1/10-9/10) to 7/10 (range: 2/10-10/10) after a mean follow-up of 21 months (range: 8-32 months) and a mean number of 2 PDT (range: 1-6). Visual acuity remained stable or improved in 13 of the 16 eyes (81%) and decreased in three.

CONCLUSION:

This nearly two-year follow-up study suggests that PDT could be helpful for patients with subfoveal classic CNV related to PIC or POHS-like.

• Authors: Laurence Postelmans, Brigitte Pasteels, Pascale Coquelet, Laure Caspers, Claire Verougstraete, Anita Leys, Mieke Wirix, Martine Mauget-Faÿsse, Maddalena Quanranta, Bernadette Snyers, Erica Smets
• Journal: Ocular immunology and inflammation (Ocul Immunol Inflamm) 2005 Sep-Oct Vol. 13 Issue 5 Pg. 361-6 ISSN: 0927-3948 [Print] England
• PMID: 16419421 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Photosensitizing Agents
• Porphyrins
• Verteporfin

Topics

• Adolescent
• Adult
• Choroidal Neovascularization (drug therapy, etiology)
• Eye Infections, Fungal (complications, drug therapy)
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Fovea Centralis
• Fundus Oculi
• Histoplasmosis (complications, drug therapy)
• Humans
• Male
• Middle Aged
• Photochemotherapy
• Photosensitizing Agents (therapeutic use)
• Porphyrins (therapeutic use)
• Retrospective Studies
• Syndrome
• Treatment Outcome
• Verteporfin
• Visual Acuity