Myelodysplastic syndrome with transformation to acute monocytic leukemia with FLT3-ITD mutation following orthotopic liver transplantation.

Abstract

A rare case of a 46-year-old man who underwent myelodysplastic syndrome, acute monocytic leukemia with FLT3-ITD mutation and splenic disruption following orthotopic liver transplantation is reported. The study of this case may be helpful to understand both the pathogenesis of acute leukemia and new complication of liver transplantation.

• Authors: Guang-Sen Zhang, Chong-Wen Dai, Hong-Lin Peng, Yun-Xiao Xu, Min-Fei Pei
• Journal: Leukemia research (Leuk Res) Vol. 30 Issue 7 Pg. 908-10 (Jul 2006) ISSN: 0145-2126 [Print] England
• PMID: 16417920 (Publication Type: Case Reports, Letter, Research Support, Non-U.S. Gov't)

Chemical References

• FLT3 protein, human
• fms-Like Tyrosine Kinase 3

Topics

• Gene Duplication
• Humans
• Leukemia, Monocytic, Acute (etiology, genetics, therapy)
• Liver Transplantation (adverse effects)
• Male
• Middle Aged
• Mutation
• Myelodysplastic Syndromes (complications, genetics, therapy)
• Reverse Transcriptase Polymerase Chain Reaction (methods)
• Sensitivity and Specificity
• fms-Like Tyrosine Kinase 3 (genetics)