Abstract | OBJECTIVE: METHODS: Ninety patients with RA were randomly divided into the treated group and the control group. The treated group was administered orally with SGDG 6 g each time, thrice a day, while the control group with the combined therapy of Fenbid Capsules 0.3 g each time, twice a day and Tripterygium tablet 20 mg each time, thrice a day. The treatment course for both groups was 6 weeks. The changes of clinical symptoms and signs, and laboratory indices such as erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), antistreptolysin O (ASO), routine examination of blood and urine, liver and kidney function, etc. before and after treatment were observed. RESULTS: (1) The total effective rate in the treated group (88.0%) was obviously higher than that in the control group (67.5%) with significant difference (P < 0.05). (2) The improvement in arthralgia, joint swelling, time of morning stiffness, 15-meter walking, analgesia initiation and persistence in the treated group was better than that in the control group (P < 0.05, P < 0.01), but there was no obvious difference in improvement of joint tenderness, range of joint motion, grip strength, and initiating detumescence time (P > 0.05). (3) The improvement in ESR and RF in the treated group was better than that in the control group with significant difference (P < 0.05). The negative-conversion rate of ASO in the treated group was also higher than that in the control group (P < 0.01). (4) No evident abnormality in blood, urine, liver or kidney function was found in either group. CONCLUSION: SGDG is effective and safe for the treatment of RA.
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Authors | Wen-ya Yu, Shu-wen Shen, Zhi-hong Yang |
Journal | Chinese journal of integrative medicine
(Chin J Integr Med)
Vol. 11
Issue 4
Pg. 255-9
(Dec 2005)
ISSN: 1672-0415 [Print] China |
PMID | 16417774
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- Plant Preparations
- fenbid
- suogudan
- Antistreptolysin
- Rheumatoid Factor
|
Topics |
- Administration, Oral
- Adult
- Aged
- Antistreptolysin
(analysis)
- Arthritis, Rheumatoid
(drug therapy)
- Blood Sedimentation
- Drugs, Chinese Herbal
(administration & dosage)
- Female
- Humans
- Male
- Middle Aged
- Phytotherapy
- Plant Preparations
(administration & dosage)
- Rheumatoid Factor
(analysis)
- Tripterygium
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