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A clinical study of Suogudan granule in the treatment of rheumatoid arthritis.

AbstractOBJECTIVE:
To study the clinical efficacy of Suogudan Granule (SGDG) in the treatment of rheumatoid arthritis (RA).
METHODS:
Ninety patients with RA were randomly divided into the treated group and the control group. The treated group was administered orally with SGDG 6 g each time, thrice a day, while the control group with the combined therapy of Fenbid Capsules 0.3 g each time, twice a day and Tripterygium tablet 20 mg each time, thrice a day. The treatment course for both groups was 6 weeks. The changes of clinical symptoms and signs, and laboratory indices such as erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), antistreptolysin O (ASO), routine examination of blood and urine, liver and kidney function, etc. before and after treatment were observed.
RESULTS:
(1) The total effective rate in the treated group (88.0%) was obviously higher than that in the control group (67.5%) with significant difference (P < 0.05). (2) The improvement in arthralgia, joint swelling, time of morning stiffness, 15-meter walking, analgesia initiation and persistence in the treated group was better than that in the control group (P < 0.05, P < 0.01), but there was no obvious difference in improvement of joint tenderness, range of joint motion, grip strength, and initiating detumescence time (P > 0.05). (3) The improvement in ESR and RF in the treated group was better than that in the control group with significant difference (P < 0.05). The negative-conversion rate of ASO in the treated group was also higher than that in the control group (P < 0.01). (4) No evident abnormality in blood, urine, liver or kidney function was found in either group.
CONCLUSION:
SGDG is effective and safe for the treatment of RA.
AuthorsWen-ya Yu, Shu-wen Shen, Zhi-hong Yang
JournalChinese journal of integrative medicine (Chin J Integr Med) Vol. 11 Issue 4 Pg. 255-9 (Dec 2005) ISSN: 1672-0415 [Print] China
PMID16417774 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Drugs, Chinese Herbal
  • Plant Preparations
  • fenbid
  • suogudan
  • Antistreptolysin
  • Rheumatoid Factor
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Antistreptolysin (analysis)
  • Arthritis, Rheumatoid (drug therapy)
  • Blood Sedimentation
  • Drugs, Chinese Herbal (administration & dosage)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phytotherapy
  • Plant Preparations (administration & dosage)
  • Rheumatoid Factor (analysis)
  • Tripterygium

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