Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches.

The present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 microg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster.
AuthorsSun-A Cho, Jong-Hwan Park, Seung-Hyeok Seok, Jae-Hyeon Juhn, Seong-Jin Kim, Hyi-Jeong Ji, Youn-Sung Choo, Jae-Hak Park
JournalExperimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (Exp Toxicol Pathol) Vol. 57 Issue 4 Pg. 321-8 (Mar 2006) ISSN: 0940-2993 [Print] Germany
PMID16414253 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Ulcer Agents
  • Biomarkers
  • Recombinant Proteins
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Fluorouracil
  • Administration, Topical
  • Animals
  • Anti-Ulcer Agents (therapeutic use)
  • Biomarkers (metabolism)
  • Cricetinae
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Fluorouracil (toxicity)
  • Granulocyte-Macrophage Colony-Stimulating Factor (therapeutic use)
  • Male
  • Mesocricetus
  • Mouth Mucosa (drug effects, metabolism, pathology)
  • Oral Ulcer (chemically induced, drug therapy, pathology)
  • Recombinant Proteins
  • Stomatitis (chemically induced, drug therapy, pathology)

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