Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches.

Abstract

The present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 microg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster.

• Authors: Sun-A Cho, Jong-Hwan Park, Seung-Hyeok Seok, Jae-Hyeon Juhn, Seong-Jin Kim, Hyi-Jeong Ji, Youn-Sung Choo, Jae-Hak Park
• Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie (Exp Toxicol Pathol) Vol. 57 Issue 4 Pg. 321-8 (Mar 2006) ISSN: 0940-2993 [Print] Germany
• PMID: 16414253 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Ulcer Agents
• Biomarkers
• Recombinant Proteins
• Granulocyte-Macrophage Colony-Stimulating Factor
• Fluorouracil

Topics

• Administration, Topical
• Animals
• Anti-Ulcer Agents (therapeutic use)
• Biomarkers (metabolism)
• Cricetinae
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Fluorouracil (toxicity)
• Granulocyte-Macrophage Colony-Stimulating Factor (therapeutic use)
• Male
• Mesocricetus
• Mouth Mucosa (drug effects, metabolism, pathology)
• Oral Ulcer (chemically induced, drug therapy, pathology)
• Recombinant Proteins
• Stomatitis (chemically induced, drug therapy, pathology)