Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats.
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| Abstract |
The current study examined the relationship between skeletal muscle levels of adiponectin and parameters of insulin sensitivity. A high fat/sucrose diet (HFD) for 20 weeks resulted in significant increases in body weight, serum insulin, triglycerides (TG), and free fatty acids (FFA) (all p < 0.01). Interestingly, this diet leads to a slight increase in serum adiponectin, but significant decreases in gastrocnemius muscle and white adipose adiponectin (all p < 0.05). HFD for 4 weeks also resulted in a significant decrease in muscle adiponectin, which correlated with serum insulin, TG, and FFA (all p < 0.05). Treatment of the 4-week HFD rats with a PPARgamma agonist GI262570 ameliorated the diet-induced hyperinsulinemia and dyslipidemia, and effectively restored muscle adiponectin (all p < 0.05). This study demonstrated that HFD-induced hyperinsulinemia and dyslipidemia appeared without changes in serum adiponectin, but were associated with decreased tissue adiponectin. This provides the first evidence for a connection between tissue adiponectin and diet-induced hyperinsulinemia and dyslipidemia.
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| Authors | Baichun Yang, Lihong Chen, Ying Qian, James A Triantafillou, Judi A McNulty, Kevin Carrick, Lisa G Clifton, Bajin Han, Robert Geske, Jay Strum, Kathleen K Brown, Stephen A Stimpson, Greg Pahel |
| Journal | Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 341 Issue 1 Pg. 209-17 (Mar 03 2006) ISSN: 0006-291X [Print] United States |
| PMID | 16414018 (Publication Type: Journal Article) |
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