[The detection of inflammation and the formation of HAMA following the administration of monoclonal antibody BW 250/183].

Abstract

Experiences with the use of the 99mTc-labelled MAb BW 250/183 in the detection of inflammatory lesions are reported. In 160 of 354 investigated patients the results could be confirmed by other methods. The sensitivity (91%) and the specificity (82%) were very high for a diagnostic tool and were comparable with the results of other leukocyte scans as reported in the literature. The positive predictive value of the method was 93%. In 84 patients studied once and in 6 patients studied twice only one case of the latter group showed a positive HAMA response. It may be concluded that the detection of foci of inflammation with the 99mTc-labelled MAb BW 250/183 is of great diagnostic value and that its administration can be repeated without risk.

• Authors: R Berberich, P Hennes, C Alexander
• Journal: Nuklearmedizin. Nuclear medicine (Nuklearmedizin) Vol. 31 Issue 3 Pg. 70-3 (Jun 1992) ISSN: 0029-5566 [Print] Germany
• Vernacular Title: Entzündungsnachweis und HAMA-Bildung nach Applikation des monoklonalen Antikörpers BW 250/183.
• PMID: 1641357 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Anti-Idiotypic
• Antibodies, Monoclonal
• Technetium

Topics

• Adult
• Animals
• Antibodies, Anti-Idiotypic (analysis)
• Antibodies, Monoclonal
• Humans
• Inflammation (diagnostic imaging, immunology)
• Male
• Mice (immunology)
• Radionuclide Imaging
• Sensitivity and Specificity
• Technetium