Injectable biopolymers enhance angiogenesis after myocardial infarction.

Abstract

Novel strategies by which to repair ischemic myocardium after myocardial infarction include the use of three-dimensional polymer scaffolds. A comparative study was carried out to assess the therapeutic potential of fibrin, collagen I, and Matrigel as injectable biopolymers for repair after myocardial infarction. Using a rat model of left coronary artery occlusion followed by reperfusion, local injection of the biopolymers into the infarct zone yielded significantly higher levels of capillary formation, when compared with the saline control group, at 5 weeks posttreatment. However, the degree of angiogenesis was not significantly different among the biopolymers. In addition, the collagen biopolymer significantly enhanced infiltration of myofibroblasts into the infarct area when compared with the control group. The results of this study highlight the potential clinical benefit of these biopolymers as injectable scaffolds or cell delivery vehicles to the infarct zone after infarction.

• Authors: Ngan F Huang, Jiashing Yu, Richard Sievers, Song Li, Randall J Lee
• Journal: Tissue engineering (Tissue Eng) 2005 Nov-Dec Vol. 11 Issue 11-12 Pg. 1860-6 ISSN: 1076-3279 [Print] United States
• PMID: 16411832 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Biocompatible Materials
• Collagen Type I
• Drug Combinations
• Laminin
• Proteoglycans
• matrigel
• Fibrin
• Collagen

Topics

• Animals
• Biocompatible Materials (administration & dosage)
• Cattle
• Cell Transplantation
• Collagen (administration & dosage)
• Collagen Type I (administration & dosage)
• Drug Combinations
• Female
• Fibrin (administration & dosage)
• Laminin (administration & dosage)
• Myocardial Reperfusion Injury (drug therapy)
• Neovascularization, Physiologic (drug effects)
• Proteoglycans (administration & dosage)
• Rats
• Rats, Sprague-Dawley