The effects of epidural deracoxib on the ground reaction forces in an acute stifle synovitis model.

Abstract

OBJECTIVE:

To evaluate the efficacy of epidurally administered deracoxib to mediate the signs of a sodium urate crystal-induced stifle synovitis in dogs, and to compare the efficacy of epidural versus subcutaneously administered deracoxib.

STUDY DESIGN:

Experimental, randomized, blinded, placebo-controlled modified cross-over design.

ANIMALS:

Random source, adult, mixed breed dogs (n = 24; 14 males, 10 females).

METHODS:

Sodium urate crystals were used to create a stifle synovitis model to evaluate the efficacy of deracoxib. Dogs were divided into 4 groups: 3 mg/kg epidural deracoxib, 1.5 mg/kg epidural deracoxib, 3 mg/kg subcutaneous deracoxib, and a placebo (vehicle for deracoxib). Force plate and subjective evaluations were made at time 0, 2, 4, 8, 12, and 24 hours post-treatment. Repeated measures ANOVA with Bonferroni-corrected post hoc comparisons was used to determine significant treatment effects.

RESULTS:

Peak vertical force (PVF) and vertical impulse (VI) were both significantly higher in deracoxib treated dogs compared with placebo. For 3 mg/kg epidural and subcutaneous deracoxib, PVF and VI were significantly greater than for 1.5 mg/kg epidural deracoxib. Overall pain score for all deracoxib-treated dogs was significantly lower than for placebo dogs.

CONCLUSIONS:

Epidural administration of deracoxib is effective at providing analgesia in an acute joint pain model; however, it does not appear to be more effective than systemic administration.

CLINICAL RELEVANCE:

Injectable deracoxib is effective in providing analgesia in acute inflammatory conditions of synovial joints.

• Authors: Priti S Karnik, Spencer Johnston, Daniel Ward, Richard Broadstone, Karen Inzana
• Journal: Veterinary surgery : VS (Vet Surg) Vol. 35 Issue 1 Pg. 34-42 (Jan 2006) ISSN: 0161-3499 [Print] United States
• PMID: 16409407 (Publication Type: Journal Article)

Chemical References

• Analgesics
• Sulfonamides
• Uric Acid
• deracoxib

Topics

• Analgesics (administration & dosage, therapeutic use)
• Analysis of Variance
• Animals
• Cross-Over Studies
• Dog Diseases (drug therapy)
• Dogs
• Dose-Response Relationship, Drug
• Female
• Injections, Epidural (veterinary)
• Injections, Subcutaneous (veterinary)
• Male
• Random Allocation
• Stifle
• Sulfonamides (administration & dosage, therapeutic use)
• Synovitis (drug therapy, veterinary)
• Treatment Outcome
• Uric Acid (toxicity)