Abstract | OBJECTIVE: To evaluate the efficacy of epidurally administered deracoxib to mediate the signs of a sodium urate crystal-induced stifle synovitis in dogs, and to compare the efficacy of epidural versus subcutaneously administered deracoxib. STUDY DESIGN: Experimental, randomized, blinded, placebo-controlled modified cross-over design. ANIMALS: Random source, adult, mixed breed dogs (n = 24; 14 males, 10 females). METHODS:
Sodium urate crystals were used to create a stifle synovitis model to evaluate the efficacy of deracoxib. Dogs were divided into 4 groups: 3 mg/kg epidural deracoxib, 1.5 mg/kg epidural deracoxib, 3 mg/kg subcutaneous deracoxib, and a placebo (vehicle for deracoxib). Force plate and subjective evaluations were made at time 0, 2, 4, 8, 12, and 24 hours post-treatment. Repeated measures ANOVA with Bonferroni-corrected post hoc comparisons was used to determine significant treatment effects. RESULTS: Peak vertical force (PVF) and vertical impulse (VI) were both significantly higher in deracoxib treated dogs compared with placebo. For 3 mg/kg epidural and subcutaneous deracoxib, PVF and VI were significantly greater than for 1.5 mg/kg epidural deracoxib. Overall pain score for all deracoxib-treated dogs was significantly lower than for placebo dogs. CONCLUSIONS: Epidural administration of deracoxib is effective at providing analgesia in an acute joint pain model; however, it does not appear to be more effective than systemic administration. CLINICAL RELEVANCE:
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Authors | Priti S Karnik, Spencer Johnston, Daniel Ward, Richard Broadstone, Karen Inzana |
Journal | Veterinary surgery : VS
(Vet Surg)
Vol. 35
Issue 1
Pg. 34-42
(Jan 2006)
ISSN: 0161-3499 [Print] United States |
PMID | 16409407
(Publication Type: Journal Article)
|
Chemical References |
- Analgesics
- Sulfonamides
- Uric Acid
- deracoxib
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Topics |
- Analgesics
(administration & dosage, therapeutic use)
- Analysis of Variance
- Animals
- Cross-Over Studies
- Dog Diseases
(drug therapy)
- Dogs
- Dose-Response Relationship, Drug
- Female
- Injections, Epidural
(veterinary)
- Injections, Subcutaneous
(veterinary)
- Male
- Random Allocation
- Stifle
- Sulfonamides
(administration & dosage, therapeutic use)
- Synovitis
(drug therapy, veterinary)
- Treatment Outcome
- Uric Acid
(toxicity)
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