Cd4+Cd25+ regulatory T cells and their therapeutic potential.

Abstract

The human immune system mounts specific responses to a vast array of antigens. Although this is clearly beneficial in fighting off harmful infections and cancerous cells, the system must be carefully controlled to ensure that normal self-antigens are not targeted. A recently characterized subset of T cells, identified by their cell surface expression of CD4 and CD25, is critical in regulating the function of other immune cells and preventing potentially harmful autoimmune responses. This article reviews what is currently known about these so-called regulatory T cells and discusses the therapeutic potential of these cells to modulate human immune-based diseases.

• Authors: David A Randolph, C Garrison Fathman
• Journal: Annual review of medicine (Annu Rev Med) Vol. 57 Pg. 381-402 ( 2006) ISSN: 0066-4219 [Print] United States
• PMID: 16409156 (Publication Type: Journal Article, Review)

Chemical References

• Interleukin-2
• Receptors, Interleukin-2

Topics

• Diabetes Mellitus, Type 1 (immunology, therapy)
• Graft vs Host Disease (immunology, therapy)
• Humans
• Interleukin-2 (physiology)
• Multiple Sclerosis (immunology, therapy)
• Receptors, Interleukin-2 (physiology)
• T-Cell Antigen Receptor Specificity (physiology)
• T-Lymphocytes, Regulatory (physiology)