[Leukocyte-modulating and antioxidant activity of blood serum and bronchoalveolar lavage fluid in the course of the decompression period of long crush syndrome].

Abstract

We studied leukocyte-modulating activity (LMA) and antioxidant activity (AOA) of blood serum and bronchoalveolar lavage fluid (BAL) in the course of a postcompression period of crush syndrome (CS) in rats. CS was modelled by compression of the left back leg of the animal with metal vice (compression area 5 cm2, duration 4 hours). In CS decompression, LMA of both the serum and BAL was high. On decompression day 1 there was a compensatory growth of serum and BAL AOA, its fall on day 3 and 7 and recovery by day 21. Calculation of the coefficient of LMA to AOA shows imbalance between pro- and antioxidant systems with development of oxidant stress. Thus, prevalence of blood and lung LMA over AOA on intermediate stages of CS may cause stimulation of destruction in hepatic and pulmonary tissues with development of inflammatory reaction.

• Authors: A V Efremov, D D Tsyrendorzhiev, Iu V Nacharov, E N Samsonova, V Iu Radustov
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 2005 Oct-Dec Issue 4 Pg. 29-31 ISSN: 0031-2991 [Print] Russia (Federation)
• PMID: 16408666 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants

Topics

• Animals
• Antioxidants (metabolism)
• Bronchoalveolar Lavage Fluid
• Crush Syndrome (blood, metabolism)
• Decompression
• Leukocytes (physiology)
• Male
• Oxidative Stress
• Rats
• Rats, Wistar
• Serum (metabolism)