[Additive effect of intravenous prednisolone for acute severe asthma in infants and toddlers: a randomized controlled clinical trial].

The efficacy of systemic corticosteroids for infants and toddlers with acute severe asthma has been inadequately evaluated.
The purpose of this study was to evaluate the additive efficacy of intravenous prednisolone in a randomized controlled study in the management of infants and toddlers with acute severe asthma.
Sixty-two patients (aged 8 to 70 months) hospitalized with status asthmaticus were studied. They were randomized into two groups. One group received intravenous prednisolone treatment (1 approximately 3 mg/kg/day, 3 days); the other group served as a control. Each group received continuous aminophylline infusion and low-dose continuous isoproterenol inhalation by an Inspiron nebulizer. They were monitored their heart rate, respiratory rate and symptoms (Wood's clinical score).
Each group showed rapid improvement in heart rate, respiratory rate and clinical score by low-dose continuous isoproterenol inhalation. There were no significant differences in the time course of these clinical indexes or the duration of aminophylline infusion, continuous isoproterenol inhalation and hospital stay.
This study failed to confirm the additive benefit of intravenous prednisolone in the management of infants and toddlers with acute severe asthma.
AuthorsMasahiko Aoyagi, Hiroyuki Kojima, Kazuki Sato, Hiroko Watanabe, Kunio Sekine, Toshiyuki Nishimuta
JournalArerugī = [Allergy] (Arerugi) Vol. 54 Issue 10 Pg. 1190-6 (Oct 2005) ISSN: 0021-4884 [Print] Japan
PMID16407665 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Aminophylline
  • Prednisolone
  • Isoproterenol
  • Acute Disease
  • Administration, Inhalation
  • Aminophylline (administration & dosage)
  • Child, Preschool
  • Drug Synergism
  • Drug Therapy, Combination
  • Female
  • Humans
  • Infant
  • Infusions, Intravenous
  • Isoproterenol (administration & dosage)
  • Male
  • Prednisolone (administration & dosage)
  • Severity of Illness Index
  • Status Asthmaticus (drug therapy)

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