Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes.

Abstract	Cinnamaldehyde from the bark of Cinnamomum cassia has been reported to have antitumor activity mediated by the inhibition of farnesyl transferase. We assessed in vivo the chemo-preventive effect of cinnamaldehydes on H-ras12V-induced hepatocellular carcinoma formation. A mouse model of hepatocellular carcinoma was established by using the transgene of mutated H-ras12V under the regulation of albumin enhancer/promoter. When treated with cinnamaldehyde for 10 weeks, hepatic tumor development was delayed with 2'-benzoyloxycinnamaldehyde (BCA) compared with control hepatocellular carcinoma formation. The effect of 2'-hydroxycinnamaldehyde (HCA) was comparable. The number of lesions and the size of each lesion were significantly reduced by BCA. Cell proliferation in the lesion was detected by incorporation of 5-bromo-2'-deoxyuridine (BrdU). BCA increased the number of splenocytes, concanavalin A-stimulated splenocyte proliferation and the infiltration of lymphocytes into liver. Data suggest that the delayed hepatic tumor development observed with BCA could be mediated by a long-term immunostimulating effect on T cells.
Authors	Eun-Yi Moon, Mi-Ran Lee, Ai-Guo Wang, Jun-Hee Lee, Hyoung-Chin Kim, Hwan-Mook Kim, Jin-Man Kim, Byoung-Mog Kwon, Dae-Yeul Yu
Journal	European journal of pharmacology (Eur J Pharmacol) Vol. 530 Issue 3 Pg. 270-5 (Jan 20 2006) ISSN: 0014-2999 [Print] Netherlands
PMID	16405947 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	2'-benzoyloxycinnamaldehyde Antineoplastic Agents Antineoplastic Agents, Phytogenic Benzoates Acrolein cinnamaldehyde
Topics	Acrolein (analogs & derivatives, pharmacology) Animals Antineoplastic Agents (pharmacology) Antineoplastic Agents, Phytogenic (pharmacology) Benzoates (pharmacology) Carcinoma, Hepatocellular (drug therapy, genetics, pathology) Cell Proliferation (drug effects) Female Genes, ras (genetics) Hepatocytes (drug effects, metabolism) Liver Neoplasms, Experimental (drug therapy, genetics, pathology) Male Mice Mice, Inbred C57BL Mice, Transgenic NIH 3T3 Cells Spleen (cytology) Tumor Burden (drug effects)

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