| Abstract | The paper presents the comparative results of clinical and immunological studies dealing with the use of the physiological reparation regulators (the human amniotic membrane and systemic enzyme therapy) and the antimetabolite 5-fluorouracil (5-FU) to prevent excessive ocular tissue scarring. The clinical observations have demonstrated the high efficiency of the proposed methods for the physiological regulation of reparative processes as compared with the use of 5-FU, which manifested as a more marked normalization ofophthalmotonus and fewer numbers of postoperative complications. The investigation of the study of proliferation-activating cytokine (TGF-beta1) and antiprolerative cytokine (IFN-gamma) has demonstrated the immunomodulating properties of the physiological reparation regulators used in the present study. |
| Authors | N I Kurysheva, S A Marnyhk, S A Borzinok, M V Bochkarev, E N Dolgina, M V Kizeev |
| Journal | Vestnik oftalmologii
(Vestn Oftalmol)
2005 Nov-Dec
Vol. 121
Issue 6
Pg. 21-5
ISSN: 0042-465X Russia (Federation) |
| PMID | 16405058
(Publication Type: Comparative Study, English Abstract, Journal Article)
|
| Chemical References |
- Immunosuppressive Agents
- TGFB1 protein, human
- Transforming Growth Factor beta
- Transforming Growth Factor beta1
- Fluorouracil
- Interferon-gamma
|
| Topics |
- Aged
- Aged, 80 and over
- Amnion
(transplantation)
- Biological Dressings
- Cicatrix
(immunology, metabolism, prevention & control)
- Female
- Fluorouracil
(therapeutic use)
- Follow-Up Studies
- Glaucoma, Open-Angle
(surgery)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Interferon-gamma
(metabolism)
- Male
- Middle Aged
- Postoperative Complications
(prevention & control)
- Tears
(metabolism)
- Trabeculectomy
(methods)
- Transforming Growth Factor beta
(metabolism)
- Transforming Growth Factor beta1
- Treatment Outcome
- Wound Healing
(immunology)
|
