[The influence of aminostigmine on the parameters of nonspecific resistance and immune system of the organism upon acute poisoning of benzyl 3-quinuclidylate].

Abstract

The results of experiments on outbred rats weighing 180 -240 g showed that the acute poisoning with benzyl 3-quinuclidylate decreases the parameters of nonspecific resistance of the organism, reduces the antibody production mainly to T-dependent antigens (sheep red blood cells), decreases the activity of natural killers and the antibody-dependent cell-mediated cytotoxicity, and suppresses the formation of delayed-type hypersensitivity. Aminostigmine partly inhibits the immunotoxicity benzyl 3-quinuclidylate.

• Authors: P F Zabrodskiĭ, N M Troshkin, V G Germanchuk, N M Sidel'nikova, V G Lim
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2005 Nov-Dec Vol. 68 Issue 6 Pg. 40-2 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 16405033 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carbamates
• Muscarinic Antagonists
• Pyridines
• Quinuclidinyl Benzilate
• aminostigmine
• Pyridostigmine Bromide

Topics

• Animals
• Antibody Formation (drug effects, immunology)
• Antibody-Dependent Cell Cytotoxicity (drug effects, immunology)
• Carbamates (administration & dosage, immunology)
• Chemical Warfare
• Killer Cells, Natural (drug effects, immunology)
• Muscarinic Antagonists (immunology, poisoning)
• Pyridines (administration & dosage, immunology)
• Pyridostigmine Bromide (administration & dosage, analogs & derivatives, immunology)
• Quinuclidinyl Benzilate (antagonists & inhibitors, immunology, poisoning)
• Rats