Abstract |
It has been established that pretreatment with the selective mu-opioid receptor (OR) agonist DALDA (0.1 mg/kg, i.v.) or the selective delta1-OR agonists DPDPE (0.09 mg/kg) and/or (-)-TAN-67 (0.08 mg/kg) has no effect on the incidence of ventricular arrhythmias induced by a 10-min coronary artery occlusion and a 10-min reperfusion in ketamine-anesthetized rats. In contrast, the pretreatment with the selective delta2-OR agonist deltorphin II (0.12 mg/kg) and the proposed delta2-OR agonists deltorphin D (0.3 mg/kg) and/or dermorphin H (0.23 mg/kg) increases cardiac resistance to the arrhythmogenic action of acute ischemia and reperfusion. Administration of the mixed mu- and delta-OR agonist dalargin (0.12 mg/kg) 15 min before the coronary artery ligation abolished only the reperfusive ventricular fibrillation. It is concluded that peptidergic stimulation of delta2-ORs can be used as a new means of increasing cardiac tolerance to the arrhythmogenic effects of acute ischemia and reperfusion.
|
Authors | N V Solenkova, L N Maslov, E V Budankova, A Iu Lishmanov, P Oeltgen, M Govindaswami, Zh D Bespalova, M V Ovchinnikov, H Nagaze |
Journal | Eksperimental'naia i klinicheskaia farmakologiia
(Eksp Klin Farmakol)
2005 Nov-Dec
Vol. 68
Issue 6
Pg. 25-9
ISSN: 0869-2092 [Print] Russia (Federation) |
PMID | 16405030
(Publication Type: Comparative Study, English Abstract, Journal Article)
|
Chemical References |
- Anti-Arrhythmia Agents
- Receptors, Opioid, delta
- Receptors, Opioid, mu
|
Topics |
- Animals
- Anti-Arrhythmia Agents
(pharmacology)
- Male
- Myocardial Reperfusion Injury
(complications, metabolism, prevention & control)
- Organ Culture Techniques
- Rats
- Rats, Wistar
- Receptors, Opioid, delta
(agonists)
- Receptors, Opioid, mu
(agonists)
- Ventricular Fibrillation
(etiology, prevention & control)
|