| Abstract | AIMS: Orlistat promotes weight loss in overweight and obese patients with Type 2 diabetes receiving hypoglycaemic treatment, but has not been investigated in patients with newly diagnosed and previously untreated Type 2 diabetes. We evaluated the efficacy of 24 weeks' treatment with orlistat, combined with a mildly reduced-calorie diet, on weight loss and glycaemic control in overweight and obese patients with newly diagnosed and previously untreated Type 2 diabetes. METHODS: A total of 249 Chinese patients (body mass index 25-40 kg/m2) with recently diagnosed Type 2 diabetes were randomized to placebo (n=124) or orlistat 120 mg (n=125) three times daily; all patients followed a mildly reduced-calorie diet. Patients had HbA1c 6.5-8.5% (mean 7.3%) and had never received any glucose-lowering medication. RESULTS: Orlistat-treated patients achieved significantly greater weight loss at the study end than placebo-treated patients (-5.4 vs. -2.4 kg; P<0.0001). More orlistat than placebo patients lost>or=5% (60.5 vs. 26.8%; P<0.0001) and >or=10% of their body weight (20.2 vs. 4.9%; P=0.0002). A significantly greater decrease in HbA(1c) from baseline was obtained with orlistat than placebo (-1.0 vs. -0.6%; P=0.0008). Orlistat-treated patients achieved a significantly greater decrease in fasting plasma glucose (-1.3 vs. -0.5 mmol/l; P=0.0003) and in the 2-h oral glucose tolerance test (-4.1 vs. -1.4 mmol/l; P<0.0001) than placebo recipients. Also, more orlistat- than placebo-treated patients improved from diabetic status to normal or impaired glucose tolerance (44.3 vs. 32.5%; P=0.0763) after 24 weeks. Orlistat also produced improvements in lipid profiles and waist circumference. CONCLUSIONS: In combination with a mildly reduced-calorie diet, orlistat significantly reduces body weight, and improves glycaemic control and several cardiovascular risk factors in overweight and obese Chinese patients with newly diagnosed Type 2 diabetes. |
| Authors | Y-F Shi, C-Y Pan, J Hill, Y Gao
(Affiliation: Department of Endocrinology, Peking Union Medical College Hospital, Beijing, China. zhuhj at 95777.com)
|
| Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 22
Issue 12
Pg. 1737-43
(Dec 2005)
ISSN: 0742-3071 England |
| PMID | 16401321
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-Obesity Agents
- Blood Glucose
- Hemoglobin A, Glycosylated
- Lactones
- orlistat
|
| Topics |
- Adolescent
- Adult
- Aged
- Anti-Obesity Agents
(therapeutic use)
- Asian Continental Ancestry Group
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Type 2
(diet therapy, drug therapy)
- Diet, Reducing
- Female
- Hemoglobin A, Glycosylated
(metabolism)
- Humans
- Lactones
(therapeutic use)
- Male
- Middle Aged
- Obesity
(diet therapy, drug therapy)
- Prospective Studies
- Weight Loss
(drug effects)
|
