Telmisartan: a review of its use in the management of hypertension.

Telmisartan (Micardis, Pritor), a highly selective angiotensin II (AII) type 1 (AT1) receptor antagonist, is approved for the treatment of hypertension, either as monotherapy or in combination with other antihypertensive agents. The long elimination half-life of telmisartan ensures the drug provides effective reductions in blood pressure (BP) across the entire 24-hour dosage interval. Extensive evidence from well designed clinical trials and the clinical practice setting indicates that telmisartan, either as monotherapy or in combination with other antihypertensive agents, provides long-term antihypertensive efficacy and is well tolerated in a broad spectrum of hypertensive patients, including the elderly and those with coexisting type 2 diabetes mellitus, metabolic syndrome and/or renal impairment. Notably, BP control is sustained throughout the 24-hour dosage interval, including during the last 6 hours of this period. Independent of its effect on BP, telmisartan displays favourable effects on insulin resistance, lipid levels, left ventricular hypertrophy (LVH) and renal function. The consistent antihypertensive efficacy during the entire 24-hour dosage interval and sustained BP-lowering effect in the long term, combined with its favourable tolerability profile, mean that telmisartan is a valuable first-line treatment option for the management of essential hypertension.
AuthorsAnna J Battershill, Lesley J Scott
JournalDrugs (Drugs) Vol. 66 Issue 1 Pg. 51-83 ( 2006) ISSN: 0012-6667 [Print] New Zealand
PMID16398568 (Publication Type: Comparative Study, Journal Article, Review)
Chemical References
  • Antihypertensive Agents
  • Benzimidazoles
  • Benzoates
  • Drug Combinations
  • Hydrochlorothiazide
  • telmisartan
  • Antihypertensive Agents (administration & dosage, pharmacology, therapeutic use)
  • Benzimidazoles (administration & dosage, pharmacology, therapeutic use)
  • Benzoates (administration & dosage, pharmacology, therapeutic use)
  • Blood Pressure (drug effects)
  • Diabetes Mellitus, Type 2 (complications, drug therapy)
  • Drug Combinations
  • Drug Therapy, Combination
  • Drug Tolerance
  • Humans
  • Hydrochlorothiazide (administration & dosage, therapeutic use)
  • Hypertension (complications, drug therapy)
  • Hypertension, Renal (complications, drug therapy)
  • Metabolic Syndrome X (complications, drug therapy)
  • Product Surveillance, Postmarketing
  • Randomized Controlled Trials as Topic

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