Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy in the treatment of locally advanced adenocarcinoma or adenosquamous carcinoma of the cervix uteri.

Abstract

The optimal treatment of women with locally advanced adenocarcinoma or adenosquamous carcinoma of the cervix uteri is still undefined. We report a series of four consecutive patients with locally advanced adeno- or adenosquamous carcinomas of the uterine cervix (FIGO Stages IB-IIIB) treated by concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by one to four cycles of consolidation chemotherapy with the same drug combination. After completion of this treatment all patients showed complete clinical remission. Now, after a median follow-up of 40 (range: 13.5-61) months all patients still present with no evidence of disease. Despite the low number of patients in this series we may conclude that concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy with the same drug combination is an efficacious treatment of patients with locally advanced adeno- or adenosquamous carcinomas of the cervix uteri.

• Authors: E Vrdoljak, T Boraska Jelavic, Z Saratlija-Novakovic, W Hamm
• Journal: European journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 26 Issue 6 Pg. 602-4 ( 2005) ISSN: 0392-2936 [Print] Singapore
• PMID: 16398217 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cisplatin
• Ifosfamide

Topics

• Adenocarcinoma (drug therapy, pathology, radiotherapy)
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Brachytherapy
• Carcinoma, Adenosquamous (drug therapy, pathology, radiotherapy)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Female
• Humans
• Ifosfamide (administration & dosage)
• Middle Aged
• Neoplasm Staging
• Uterine Cervical Neoplasms (drug therapy, pathology, radiotherapy)