[The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis].

Abstract

The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis. Alcohol-induced liver disease is one of the main epidemic problems of nowadays. Non-alcoholic steatohepatitis has been described only for some years, but it also needs much more attention in the future. The etiologic factors of both entities are quite different, but the pathologic changes of the liver are nearly the same, therefore there could be certain drugs, that are equally effective in their therapy. Metadoxine is one of them, mainly because its protective effect against the damage done by free radicals. Metadoxine is a pyridoxine-pyrrolidone carboxylate with significant scavenging property. There are a lot of patients suffering from steatohepatitis, and they will face the complications of the liver damage. The aim is to provide better recovery and proper quality of life, which is based on the deeper understanding of these mechanisms. Metadoxine is suitable for increasing reduced glutathione level, which is very important for the redox homeostasis of the liver and the whole body. The effectiveness of the drug is established both in acute and in chronic alcoholism, moreover it helps in staying abstinent.

• Authors: László Váli, Anna Blázovics, János Fehér
• Journal: Orvosi hetilap (Orv Hetil) Vol. 146 Issue 47 Pg. 2409-14 (Nov 20 2005) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: A metadoxin teráipiás hatásának összehasonlítása alkoholos és nem alkoholos zsírmájban.
• PMID: 16398154 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Alcohol Deterrents
• Drug Combinations
• metadoxine
• Glutathione
• Pyridoxine
• Pyrrolidonecarboxylic Acid

Topics

• Alcohol Deterrents (therapeutic use)
• Alcoholic Intoxication (drug therapy)
• Alcoholism (complications, drug therapy)
• Drug Combinations
• Fatty Liver (drug therapy)
• Fatty Liver, Alcoholic (drug therapy)
• Glutathione (metabolism)
• Hepatitis (drug therapy)
• Hepatitis, Alcoholic (drug therapy)
• Humans
• Pyridoxine (therapeutic use)
• Pyrrolidonecarboxylic Acid (therapeutic use)
• Quality of Life