Spontaneous remission of acute myeloid leukemia associated with GnRH agonist treatment.

Abstract

Spontaneous remission of acute myeloid leukemia (AML) in adults is a rare but well documented phenomenon. This study reports on a 64-year-old male patient with acute myelogenous leukemia (AML-M4, according to the French-American-British classification) that was developed on a background of chronic myelomonocytic leukemia (CMML) and then underwent remission after treatment with the gonadotropin-releasing hormone agonist (GnRH agonist) triptorelin for presumed prostate cancer. Remission persisted for at least 4 years before the patient was lost to follow-up. To the author' knowledge, this is the first report of remission in an AML-M4 case associated with hormone manipulation. Possible mechanisms of this phenomenon are discussed.

• Authors: Nicolas Tsavaris, Petros Kopterides, Christos Kosmas, Marina Siakantaris, Evangelos Patsouris, Gerasimos Pangalis
• Journal: Leukemia & lymphoma (Leuk Lymphoma) Vol. 47 Issue 3 Pg. 557-60 (Mar 2006) ISSN: 1042-8194 [Print] United States
• PMID: 16396781 (Publication Type: Case Reports, Journal Article)

Chemical References

• Triptorelin Pamoate
• Gonadotropin-Releasing Hormone

Topics

• Follow-Up Studies
• Gonadotropin-Releasing Hormone (agonists)
• Humans
• Leukemia, Myelomonocytic, Acute (diagnosis, drug therapy, pathology)
• Leukemia, Myelomonocytic, Chronic (diagnosis, drug therapy, pathology)
• Male
• Middle Aged
• Remission, Spontaneous
• Treatment Outcome
• Triptorelin Pamoate (therapeutic use)