Caffeic acid inhibits compound 48/80-induced allergic symptoms in mice.

Abstract

The effect of caffeic acid on scratching behavior and vascular permeability changes induced by compound 48/80 in ICR mice were investigated. An oral dose of 500 mg/kg of caffeic acid significantly inhibited scratching behavior and vascular permeability induced by compound 48/80. The inhibitory effects of daily administration of lower doses of caffeic acid, 100 and 200 mg/kg, were also investigated; and it was found that 200 mg/kg significantly inhibited compound 48/80-induced scratching behavior after the second week of consecutive administration. The effect of 200 mg/kg of caffeic acid on scratching behavior was observed up to the third week of the treatment. The decrease in histamine content induced by compound 48/80 was significantly antagonized by 200 mg/kg. The findings suggest that caffeic acid may be effective for treating itch and edema in allergic dermatitis.

• Authors: Maria Alejandra Hossen, Toshio Inoue, Yoshifumi Shinmei, Kazuhisa Minami, Yoko Fujii, Chiaki Kamei
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 29 Issue 1 Pg. 64-6 (Jan 2006) ISSN: 0918-6158 [Print] Japan
• PMID: 16394511 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Caffeic Acids
• Oxidants
• Superoxides
• p-Methoxy-N-methylphenethylamine
• caffeic acid

Topics

• Animals
• Antioxidants (pharmacology)
• Behavior, Animal (drug effects)
• Caffeic Acids (pharmacology)
• Capillary Permeability (drug effects)
• Female
• Histamine Release (drug effects)
• Hypersensitivity (prevention & control)
• Mice
• Mice, Inbred ICR
• Oxidants (metabolism)
• Regional Blood Flow (drug effects)
• Skin (blood supply, drug effects, metabolism)
• Superoxides (metabolism)
• p-Methoxy-N-methylphenethylamine (antagonists & inhibitors, pharmacology)