Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese.

Abstract

BACKGROUND:

Peroxisome proliferator-activated receptor gamma inhibits the growth and induces apoptosis of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.

AIM:

To study the association between peroxisome proliferator-activated receptor gamma gene polymorphism, Helicobacter pylori infection and gastric cancer in Chinese.

METHODS:

One hundred and four consecutive patients with non-cardia gastric adenocarcinoma and 104 matched controls were examined. Peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism.

RESULTS:

The frequency of peroxisome proliferator-activated receptor gamma G (Ala12) allele was significantly higher among cancer patients (19.2%) than in control (8.7%; OR 2.5, 95% CI 1.1-5.8). While H. pylori infection was more prevalent in gastric cancer patients (OR 3.0; 95% CI 1.6-5.7), the combination of peroxisome proliferator-activated receptor gamma G allele and H. pylori infection further increased the risk of gastric cancer (OR 12.8, 95% CI 3.2-50.5). The presence of the Ala12 did not increase the risk of gastric cancer in H. pylori-negative subjects.

CONCLUSION:

Our study suggests the potential association between peroxisome proliferator-activated receptor gamma polymorphism and H. pylori infection in the development of non-cardia gastric cancer.

• Authors: S-Y Liao, Z-R Zeng, W K Leung, S-Z Zhou, B Chen, J J Y Sung, P-J Hu
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 23 Issue 2 Pg. 289-94 (Jan 15 2006) ISSN: 0269-2813 [Print] England
• PMID: 16393309 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• PPAR gamma

Topics

• Adenocarcinoma (genetics, microbiology)
• Female
• Genotype
• Helicobacter pylori
• Humans
• Male
• Middle Aged
• PPAR gamma (genetics)
• Polymorphism, Restriction Fragment Length
• Risk Factors
• Stomach Neoplasms (genetics, microbiology)