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Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome.

AbstractAIM:
To determine the effect of a laxative alone and in combination with tegaserod in alleviating pain and improving stool frequency in adolescents with constipation predominant irritable bowel syndrome.
PATIENTS:
Forty-eight postpubertal adolescents of both sexes with constipation predominant irritable bowel syndrome, as defined by Rome II criteria, were randomly allocated to Group A (n = 27) for treatment with a laxative (polyethylene glycol 3350 oral solution) only or Group B (n = 21) for combination therapy with the laxative and tegaserod. Symptoms of abdominal pain (scale 0-10) and frequency of bowel movements were recorded daily in the pre-treatment phase and the post-treatment phase after a 7-day 'washout' period. Patients served as their own controls.
RESULTS:
Treatment with the laxative alone (Group A) resulted in significant increase in frequency of bowel movements (P < 0.05), but not significant improvement in pain (P > 0.05). Treatment with the combination of the laxative and tegaserod (Group B) led to significant increase in the frequency of bowel movements and also significant reduction in pain (P < 0.05).
CONCLUSIONS:
The laxative alone improved stooling but not pain in adolescents with constipation predominant irritable bowel syndrome. Addition of tegaserod resulted in alleviation of pain as well.
AuthorsV Khoshoo, C Armstead, L Landry
JournalAlimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 23 Issue 1 Pg. 191-6 (Jan 01 2006) ISSN: 0269-2813 [Print] England
PMID16393297 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Cathartics
  • Gastrointestinal Agents
  • Indoles
  • tegaserod
Topics
  • Abdominal Pain (diagnosis, drug therapy)
  • Adolescent
  • Cathartics (therapeutic use)
  • Constipation (complications, drug therapy)
  • Drug Therapy, Combination
  • Female
  • Gastrointestinal Agents (therapeutic use)
  • Humans
  • Indoles (therapeutic use)
  • Irritable Bowel Syndrome (complications, drug therapy)
  • Male
  • Pain Measurement
  • Patient Satisfaction
  • Prospective Studies

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