Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.

Abstract

Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.

• Authors: Rui Liu, Cheng-Bin Cui, Lin Duan, Qian-Qun Gu, Wei-Ming Zhu
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 28 Issue 12 Pg. 1341-4 (Dec 2005) ISSN: 0253-6269 [Print] Korea (South)
• PMID: 16392666 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Pigments, Biological
• metacycloprodigiosin
• undecylprodigiosin
• Chloroform
• Prodigiosin

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Cell Line
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Chemical Fractionation (methods)
• Chloroform (chemistry)
• HL-60 Cells
• Humans
• Mice
• Molecular Structure
• Pigments, Biological (chemistry, isolation & purification, pharmacology)
• Porifera (microbiology)
• Prodigiosin (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Saccharopolyspora (chemistry)