Abstract | PURPOSE: To evaluate controversial results regarding the effect of the contrast medium (CM) iothalamate on renal medullary blood flow by applying two different methods simultaneously. MATERIAL AND METHODS: RESULTS: CM induced a transient 28% decrease in OMBF as measured with the laser Doppler. The hydrogen gas wash-out rate was reduced by 50%, indicating a reduced perfusion. CM induced a transient 60% reduction in PO2, while renal fluid and electrolyte excretion increased several fold. CONCLUSION: The CM iothalamate reduces outer medullary perfusion as estimated by two different techniques applied simultaneously. The PO2 in the same region was also reduced. Previous controversies regarding the effect of iothalamate on OMBF can be explained by extreme dosage and injection rates greatly exceeding clinical relevance.
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Authors | P Liss, K Aukland, P O Carlsson, F Palm, P Hansell |
Journal | Acta radiologica (Stockholm, Sweden : 1987)
(Acta Radiol)
Vol. 46
Issue 8
Pg. 823-9
(Dec 2005)
ISSN: 0284-1851 [Print] England |
PMID | 16392607
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- Iothalamic Acid
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Topics |
- Animals
- Blood Pressure
(drug effects, physiology)
- Contrast Media
(administration & dosage, pharmacology)
- Injections, Intravenous
- Iothalamic Acid
(administration & dosage, pharmacology)
- Kidney Medulla
(drug effects, metabolism, physiopathology)
- Laser-Doppler Flowmetry
- Male
- Oxygen Consumption
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Renal Circulation
(drug effects, physiology)
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