| Abstract | Many patients with diabetes mellitus complain of early satiety and postprandial gastric fullness and discomfort. Mosapride citrate, a 5-HT4 receptor agonist, enhances gastric emptying and alleviates gastrointestinal discomfort in patients with diabetic gastroparesis. This study was undertaken to investigate the effects of mosapride citrate on feeding behavior in ob/ob obese mice with decreased gastric emptying. Mosapride citrate (1 mg/kg/day) was orally administered for 7 days. Food and water intake and body weight were measured daily. Blood glucose, serum insulin, and fructosamine concentrations were measured after 7 days of treatment. Orally administered mosapride citrate significantly increased food intake in ob/ob obese mice, with a tendency to decrease fasting blood glucose and fructosamine concentrations compared with controls. There were no significant changes in body weight after 7 days of treatment with oral mosapride citrate. These observations suggest that mosapride citrate may be useful in the treatment of appetite loss and improve the quality of life in patients with diabetes mellitus. |
| Authors | Akihiro Asakawa, Naohiko Ueno, Miwako Katagi, Yuka Ijuin, Yoshinori Morita, Shigeto Mizuno, Toshio Inui, Ruka Sakamaki, Naotaka Shinfuku, Msaharu Uemoto
(Affiliation: Inui Clinic, 6-14-17, Kinda, Moriguchi, Osaka 570-0011, Japan. asakawa at med.kobe-u.ac.jp)
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| Journal | Journal of diabetes and its complications
(J Diabetes Complications)
2006 Jan-Feb
Vol. 20
Issue 1
Pg. 56-8
ISSN: 1056-8727 United States |
| PMID | 16389169
(Publication Type: Journal Article)
|
| Chemical References |
- Benzamides
- Blood Glucose
- Gastrointestinal Agents
- Morpholines
- Insulin
- mosapride
- Fructosamine
|
| Topics |
- Administration, Oral
- Animals
- Benzamides
(administration & dosage, pharmacology)
- Blood Glucose
(drug effects)
- Body Weight
(drug effects)
- Eating
(drug effects)
- Fructosamine
(blood)
- Gastric Emptying
(drug effects)
- Gastrointestinal Agents
(administration & dosage, pharmacology)
- Insulin
(blood)
- Male
- Mice
- Mice, Obese
- Morpholines
(administration & dosage, pharmacology)
|
