| Abstract | AIMS: An evaluation is made of bacterial species and susceptibility to various antibiotics used in application to odontogenic infections of periapical location and in pericoronitis of the lower third molar, with the aim of optimizing the antibiotherapy of such infections and thus preventing unnecessary side effects and over-treatment. MATERIAL AND METHODS: Sixty-four patients with odontogenic infection were selected on the basis of a series of inclusion and exclusion criteria. Samples were collected from lesions under maximally aseptic conditions, avoiding oral saprophytic contamination. The samples were cultured and incubated under aerobic and anaerobic conditions, followed by bacteriological identification and antibiotic susceptibility testing. RESULTS: A total of 184 bacterial strains were isolated and identified, comprising grampositive facultative anaerobes (68%), gramnegative strict anaerobes (30%) and grampositive facultative anaerobes (2%). Regardless of the origin of the odontogenic infection, the causal bacteria yielded the best results in terms of increased sensitivity and lesser resistance with amoxicillin / clavulanate and amoxicillin, respectively (p<0.05). DISCUSSION: There are increasingly numerous reports in the literature of growing bacterial resistance to antibiotics in infectious processes affecting non-buccodental territories. This same tendency has not been observed in relation to oral infections, though important resistance has been documented for certain concrete antibiotics. According to our results, the common-use antibiotics with the greatest sensitivity and lowest resistance were shown to be amoxicillin/clavulanate followed by amoxicillin alone. |
| Authors | Miguel Brescó-Salinas, Noelia Costa-Riu, Leonardo Berini-Aytés, Cosme Gay-Escoda
(Affiliation: Barcelona University Dental School, Barcelona, Spain.)
|
| Journal | Medicina oral, patología oral y cirugía bucal
(Med Oral Patol Oral Cir Bucal)
Vol. 11
Issue 1
Pg. E70-5
(Jan 2006)
ISSN: 1698-6946 Spain |
| PMID | 16388299
(Publication Type: Journal Article)
|
| Chemical References |
- Acetamides
- Anti-Bacterial Agents
- Oxazolidinones
- linezolid
- Clindamycin
- Amoxicillin
- Metronidazole
- Tetracycline
- Amoxicillin-Potassium Clavulanate Combination
|
| Topics |
- Acetamides
(pharmacology)
- Adolescent
- Adult
- Amoxicillin
(pharmacology)
- Amoxicillin-Potassium Clavulanate Combination
(pharmacology)
- Anti-Bacterial Agents
(pharmacology)
- Bacteria, Anaerobic
(drug effects)
- Clindamycin
(pharmacology)
- Drug Resistance, Bacterial
- Female
- Focal Infection, Dental
(microbiology)
- Humans
- Male
- Metronidazole
(pharmacology)
- Microbial Sensitivity Tests
- Middle Aged
- Molar, Third
- Oxazolidinones
(pharmacology)
- Periapical Periodontitis
(microbiology)
- Pericoronitis
(microbiology)
- Tetracycline
(pharmacology)
|
