Abstract |
Neurological soft-sign abnormalities have been implicated in obsessive-compulsive disorder (OCD). This first comprehensive data analysis evaluated the association between baseline neurological soft signs and treatment response in 117 OCD patients treated with controlled-release fluvoxamine in a double-blind placebo-controlled trial. Total and right-sided soft signs for the responders and the nonresponders did not differ significantly. Left-sided visuospatial soft signs were significantly increased in treatment nonresponders compared to responders. These subtle neurological abnormalities may implicate a potential subgroup of OCD patients with poorer treatment response. This may have treatment implications and therefore serve as a screening tool in OCD.
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Authors | Eric Hollander, Alicia Kaplan, James Schmeidler, Haichen Yang, David Li, Lorrin M Koran, Luigi M Barbato |
Journal | The Journal of neuropsychiatry and clinical neurosciences
(J Neuropsychiatry Clin Neurosci)
Vol. 17
Issue 4
Pg. 472-7
( 2005)
ISSN: 0895-0172 [Print] United States |
PMID | 16387985
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Serotonin Uptake Inhibitors
- Fluvoxamine
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Topics |
- Double-Blind Method
- Fluvoxamine
(therapeutic use)
- Humans
- Obsessive-Compulsive Disorder
(drug therapy, physiopathology)
- Personality Inventory
(statistics & numerical data)
- Psychiatric Status Rating Scales
(statistics & numerical data)
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Severity of Illness Index
- Treatment Outcome
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