Abstract | PURPOSE:
IGF-I serum levels have been demonstrated as being associated with prostate cancer (PCa) and can serve as a predictive factor for the risk of PCa development. However, the role of IGF-II in PCa and its importance as a predictive marker is still unclear. Our aim was to determine PSA and IGF-II serum levels in patients with PCa and benign prostatic hyperplasia (BPH) and to analyse the value of IGF-II as an additional predictive factor in the diagnostics of PCa. METHODS: 112 patients who underwent surgery for BPH or PCa (no hormonal treatment, no further malignancies) were included in this study ((I) 38 PCa, PSA < or = 15 ng/ ml; (II) 34 PCa, PSA > 15 ng/ml; (III) 40 BPH). Preoperative serum levels of total PSA and total IGF-II were determined by ELFA and ELISA, respectively. RESULTS: PSA levels were (I) 5.7+/-1.9 ng/ ml; (II) 25.0+/-11.5 ng/ml and (III) 4.0+/-2.8 ng/ ml. (II) was statistically associated with a high grading (2b/3; p = 0.0182), a high Gleason sum score (7-10; p = 0.0049) and a non-organ confined tumor (T3/4; p = 0.0009) compared to (I), all Chi2 test. IGF-II levels were significantly higher in PCa (I+II) compared to BPH (833.8+/-238.9 ng/ml vs. 633.3+/-141.4 ng/ml, p < 0.0001, t-test). Both PSA and IGF-II were associated with tumor staging (p = 0.0097, p = 0.0308; t-test). No significant correlation was observed between PSA and IGF-II levels. Logistic regression analysis revealed that the combination of PSA and IGF-II improves the prediction of tumor staging in PCa (p = 0.0175 and p = 0.0459, Wald test). Additionally, the combination of PSA and IGF-II can significantly increase discrimination between BPH and PCa; each p < 0.0001, Wald test. CONCLUSIONS: This study provides evidence that IGF-II serum levels may serve as an additional parameter for (a) improved determination of tumor staging and (b) better discrimination between BPH and PCa.
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Authors | Lutz Trojan, Christian Bode, Christel Weiss, Doris Mayer, Rainer Grobholz, Peter Alken, Maurice Stephan Michel |
Journal | European urology
(Eur Urol)
Vol. 49
Issue 2
Pg. 286-92; discussion 292
(Feb 2006)
ISSN: 0302-2838 [Print] Switzerland |
PMID | 16386354
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Insulin-Like Growth Factor II
- Prostate-Specific Antigen
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Topics |
- Aged
- Aged, 80 and over
- Analysis of Variance
- Biomarkers, Tumor
(blood)
- Diagnosis, Differential
- Humans
- Insulin-Like Growth Factor II
(metabolism)
- Logistic Models
- Male
- Middle Aged
- Neoplasm Staging
- Predictive Value of Tests
- Prostate-Specific Antigen
(blood)
- Prostatic Hyperplasia
(blood, pathology)
- Prostatic Neoplasms
(blood, pathology)
- ROC Curve
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