Abstract |
The efficacy of orally administered flumequine in the treatment of experimentally induced vibriosis in Atlantic cod Gadus morhua was investigated. Cod (mean +/- SD, 120 +/- 30 g) were randomly distributed to twelve tanks and bath challenged for 1 h with Listonella anguillarum serotype O2alpha, strain HI-610, using a dose of 9.2 x 10(6) CFU ml(-1). At 3 d post-challenge, medication was introduced in 10 of the groups at doses of 2.5, 5, 10, 15 and 25 mg flumequine kg(-1) body weight d(-1) in duplicate. The medication was administered on Days 1, 2, 4, 6, 8, and 10 after the initiation of treatment. In challenged unmedicated fish, mortality started on Day 4 post-challenge, reaching a final cumulative mortality of 82% at Day 18. In the medicated groups, mortality started on Days 3 to 5 post-challenge, reaching final cumulative mortalities of 42, 49, 37, 37 and 23% respectively for the fish treated with 2.5, 5, 10, 15 and 25 mg flumequine kg(-1) body weight d(-1). Survival of medicated fish in all groups was significantly greater than in challenged unmedicated fish (p < 0.001). Twenty-four h following the final medication, HPLC analysis found a linear relationship between doses and mean concentrations of the drug in plasma, muscle and liver.
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Authors | Frode Todnem Vik-Mo, Oivind Bergh, Ole Bent Samuelsen |
Journal | Diseases of aquatic organisms
(Dis Aquat Organ)
Vol. 67
Issue 1-2
Pg. 87-92
(Nov 09 2005)
ISSN: 0177-5103 [Print] Germany |
PMID | 16385813
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fluoroquinolones
- flumequine
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Topics |
- Administration, Oral
- Animals
- Chromatography, High Pressure Liquid
- Dose-Response Relationship, Drug
- Fish Diseases
(drug therapy, microbiology)
- Fishes
- Fluoroquinolones
(administration & dosage, metabolism, therapeutic use)
- Gram-Negative Bacterial Infections
(drug therapy, veterinary)
- Liver
(metabolism)
- Muscle, Skeletal
(metabolism)
- Survival Analysis
- Time Factors
- Vibrionaceae
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