Abstract |
This study examined the effect of (E)-2-methyl-6-(2-phenylethynyl)-pyridine (SIB-1893), a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist, on body temperature in freely moving Wistar rats. Temperature was monitored using programmed microchips, implanted subcutaneously in rats, at several times: 0, 5, 10, 20, 30, 45, 60, 90, 120 and 180 min after intraperitoneal administration of SIB-1893 at increasing doses of 10, 20 and 30 mg/kg. The results analyzed with two-way ANOVA with repeated measures on time revealed that SIB-1893 at 30 mg/kg considerably lowered the body temperature in animals at 90, 120 and 180 min after its systemic injection. In contrast, the drug at 10 and 20 mg/kg remained without effect on the body temperature in rats. Based on our preclinical study, one can conclude that SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner.
|
Authors | Jarogniew J Łuszczki, Kinga K Borowicz, Stanisław J Czuczwar |
Journal | Pharmacological reports : PR
(Pharmacol Rep)
2005 Nov-Dec
Vol. 57
Issue 6
Pg. 795-801
ISSN: 1734-1140 [Print] Switzerland |
PMID | 16382199
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Grm5 protein, rat
- Pyridines
- Receptor, Metabotropic Glutamate 5
- Receptors, Metabotropic Glutamate
- SIB 1893
|
Topics |
- Analysis of Variance
- Animals
- Body Temperature
(drug effects)
- Dose-Response Relationship, Drug
- Hypothermia, Induced
- Male
- Pyridines
(pharmacology)
- Rats
- Rats, Wistar
- Receptor, Metabotropic Glutamate 5
- Receptors, Metabotropic Glutamate
(drug effects, metabolism)
- Time Factors
|