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Studies into the anticancer effects of selenomethionine against human colon cancer.

Abstract
Colorectal cancer is the third most frequent fatal malignant neoplasm in the United States and is expected to cause significant morbidity and mortality. The recent recall of cyclooxygenase-2 inhibitors from clinical trials highlights the need to develop other agents for cancer chemoprevention trials. Intervention strategies with selenium compounds represent a viable option to reduce colon cancer. Here we discuss epidemiologic studies and ongoing clinical trials with selenium. In addition, we discuss preclinical mechanistic studies that provide insights into the biochemical and molecular bases for the anticancer effects of selenomethionine.
AuthorsMark A Nelson, Anne-Christine Goulet, Elizabeth T Jacobs, Peter Lance
JournalAnnals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1059 Pg. 26-32 (Nov 2005) ISSN: 0077-8923 [Print] United States
PMID16382040 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antineoplastic Agents
  • Cyclooxygenase Inhibitors
  • Histones
  • Selenomethionine
  • Cyclooxygenase 2
  • Extracellular Signal-Regulated MAP Kinases
  • Selenium
Topics
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Colonic Neoplasms (drug therapy)
  • Cyclooxygenase 2 (metabolism)
  • Cyclooxygenase Inhibitors (pharmacology)
  • Extracellular Signal-Regulated MAP Kinases (metabolism)
  • Histones (metabolism)
  • Humans
  • Models, Biological
  • Selenium (metabolism)
  • Selenomethionine (pharmacology)

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