Abstract | OBJECT: METHODS: Thirteen patients, 10 of whom harbored a glioblastoma multiforme (GBM), one a gliosarcoma, one an anaplastic astrocytoma, and one an anaplastic oligoastrocytoma, were treated using this modified BNCT between January 2002 and December 2003. Postoperatively, neuroimaging revealed that only one patient with a GBM had no lesion enhancement postoperatively. The patients underwent 18F-BPA positron emission tomography, if available, to assess the accumulation and distribution of BPA before neutron radiotherapy. The neutron fluence rate was estimated using the Simulation Environments for Radiotherapy Applications dose-planning system before irradiation. The patients' volume assessments were performed using magnetic resonance (MR) imaging or computerized tomography (CT) scanning. Improvements in the disease as seen on neuroimages were assessed between 2 and 7 days after irradiation to determine the initial effects of BNCT; its maximal effects were also analyzed on serial neuroimages. The mean tumor volume before BNCT was 42.3 cm3. Regardless of the pre-BNCT tumor volume, in every patient harboring an assessable lesion, improvements on MR or CT images were recognized both at the initial assessment (range of volume reduction rate 17.4-71%, mean rate 46.4%) and at follow-up assessments (range of volume reduction rates 30.3-87.6%, mean rate 58.5%). More than 50% of the contrast-enhanced lesions disappeared in eight of the 12 patients during the follow-up period. CONCLUSIONS: This modified BNCT produced a good improvement in malignant gliomas, as seen on neuroimages.
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Authors | Shin-Ichi Miyatake, Shinji Kawabata, Yoshinaga Kajimoto, Atsushi Aoki, Kunio Yokoyama, Makoto Yamada, Toshihiko Kuroiwa, Motomu Tsuji, Yoshio Imahori, Mitsunori Kirihata, Yoshinori Sakurai, Shin-Ichiro Masunaga, Kenji Nagata, Akira Maruhashi, Koji Ono |
Journal | Journal of neurosurgery
(J Neurosurg)
Vol. 103
Issue 6
Pg. 1000-9
(Dec 2005)
ISSN: 0022-3085 [Print] United States |
PMID | 16381186
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Astrocytoma
(radiotherapy)
- Boron Compounds
(therapeutic use)
- Boron Neutron Capture Therapy
(adverse effects, methods)
- Brain Edema
(diagnosis, etiology)
- Brain Neoplasms
(complications, diagnosis, pathology, radiotherapy)
- Female
- Glioblastoma
(radiotherapy)
- Glioma
(complications, diagnosis, pathology, radiotherapy)
- Gliosarcoma
(radiotherapy)
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neutrons
- Positron-Emission Tomography
- Tomography, X-Ray Computed
- Treatment Outcome
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