Polymorphisms in the growth hormone receptor: a case-control study in breast cancer.

The human growth hormone receptor (GHR) mediates the effects of growth hormone (GH1), starting a signalling cascade that is involved in the regulation of proliferation, differentiation and apoptosis. Recently, an isoform of the GHR gene lacking exon 3 (GHRd3) was associated with accelerated responsiveness to growth hormone. In this study, we investigated the association of the GHRd3 polymorphism with breast cancer risk and performed a haplotype analysis with 3 additional single nucleotide polymorphisms (SNPs) (Gly186Gly, Cys440Phe and Ile544Leu) in the GHR coding region in a Polish cohort. We did not observe any effect of the 4 polymorphisms on breast cancer risk. Neither did the 3 most common haplotypes influence breast cancer risk. However, a rare haplotype (dGGC), containing the GHRd3 allele, was associated with a decreased breast cancer risk (OR 0.30, 95% CI 0.11-0.80).
AuthorsKerstin Wagner, Kari Hemminki, Ewa Grzybowska, Justo Lorenzo Bermejo, Dorota Butkiewicz, Jolanta Pamula, Wioletta Pekala, Asta Försti
JournalInternational journal of cancer. Journal international du cancer (Int J Cancer) Vol. 118 Issue 11 Pg. 2903-6 (Jun 1 2006) ISSN: 0020-7136 [Print] United States
PMID16381017 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carrier Proteins
  • Protein Isoforms
  • somatotropin-binding protein
  • Adult
  • Aged
  • Alleles
  • Apoptosis
  • Breast Neoplasms (genetics)
  • Carrier Proteins (genetics)
  • Case-Control Studies
  • Cell Proliferation
  • Female
  • Haplotypes
  • Humans
  • Middle Aged
  • Odds Ratio
  • Poland
  • Polymorphism, Single Nucleotide
  • Protein Isoforms

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