It is well-established that various drugs can induce esophageal and gastric mucosal injury. Generally neither motility disorder nor an anatomical
stricture is found in such cases and the cause of mucosal injury is usually found to be inadequate fluid intake with medicine or consumption just prior to bedtime. Athough there are some case reports of
doxycycline induced esophageal mucosal injury,
doxycycline induced
gastric ulcer has been reported only once in the literature. In this case report, a 33 year old female patient who had been prescribed
doxycycline for
pelvic inflammatory disease is presented. She was admitted with retrosternal and epigastric
pain and odynophagia, which had begun after taking the second oral dose of the
drug. Endoscopic examination showed
ulcers in the mid esophagus and fundus of the stomach. Histologic findings supported a
drug induced etiology in these
ulcers. This is only the second case in the literature where
gastric ulcer has been caused by
doxycycline.