|MATERIALS AND METHODS:
To introduce a newly developed polymer
-based and magnetic resonance (MR)-compatible guidewire and to explore its capabilities with respect to interventional peripheral magnetic resonance angiography (ipMRA) in a flow phantom.
The guidewire is based on a polyetheretherketone
core, and small iron
particles are embedded in its coating. A passive device tracking technique was designed utilizing a susceptibility artifact induced by the wire in images acquired with a balanced steady-state free precession (b-SSFP) sequence using small flip angles. The position of the guidewire tip was determined from image intensity maxima and overlayed onto a roadmap in near real-time. Guidewire tracking and balloon angioplasty
of an artificial stenosis
were attempted in two configurations of a flow phantom.
Successful passive guidewire tracking was performed for all phantom configurations. Robustness and accuracy of the tracking technique were sufficient for phantom studies. A balloon catheter
was placed into the stenosis
using the guidewire under complete MR guidance, and subsequent balloon angioplasty
yielded improved flow conditions.
The new guidewire is well-suited for clinical application due to an absence of the risk of core fracture and its atraumatic flexible tip. It opens novel prospects for the realization of ipMRA in humans that need to be explored in further studies.
|Authors||Ralf Mekle, Eugen Hofmann, Klaus Scheffler, Deniz Bilecen
(Affiliation: MR-Physics, University of Basel/University Hospital, Basel, Switzerland. Ralf.Mekle at unibas.ch)
|Journal||Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
ISSN: 1053-1807 [Print] United States
(Publication Type: Comparative Study, Journal Article)
|Copyright||(c) 2005 Wiley-Liss, Inc.
- Angiography, Digital Subtraction
- Image Interpretation, Computer-Assisted
- Magnetic Resonance Angiography
- Models, Anatomic
- Peripheral Vascular Diseases
- Phantoms, Imaging
- Radiology, Interventional
- Risk Factors
- Sensitivity and Specificity